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For more details about the Repaglinide drug, you can read the article given below.

What is repaglinide and how it works?

Repaglinide is an antihyperglycemic drug that is taken orally.
It belongs to the meglitinide class of short-acting insulin secretagogues, which induce insulin secretion by attaching to pancreatic cells.
Repaglinide reduces postprandial blood glucose levels by inducing an early insulin response to meals. It should only be used with meals, and doses taken at mealtime should be omitted if a meal is missed.
Repaglinide is a type of anti-diabetic drug. It causes the pancreas to release more insulin, preventing blood glucose levels from increasing too high after meals.
Repaglinide differs from other antidepressants in that it has a fast onset of action and a brief duration of activity. It increases the release of insulin that occurs naturally with meals and is responsible for preventing blood glucose levels from rising too high when taken soon before meals.
In 1997, the FDA authorized repaglinide.

Uses of Repaglinide:

Repaglinide is a medication that is used to treat type 2 diabetes. Repaglinide aids in the regulation of glucose (sugar) levels in the blood.
The medication is used to treat diabetes mellitus that is not insulin-dependent (NIDDM)
It has been demonstrated to reduce HbA1c (hemoglobin A1c) levels by 1.6 to 1.9 percent. (Hemoglobin A1c is a blood test that determines how well a medicine works in controlling high blood glucose levels over time; the lower the hemoglobin A1c, the better the control.)
Type 1 diabetes is not treated with repaglinide.
Repaglinide can be used for a variety of other things that aren't covered in this pharmaceutical guide.

General Information:

The Generic name is repaglinide (oral) (re PAG li nide)
DrugBank Accession Number: DB00912
Type: Small Molecule
Groups: Approved, Investigational
Synonyms: Repaglinida; Repaglinide; Repaglinidum
Associated Conditions: Type 2 Diabetes Mellitus
Dosage forms consist of oral tablet (0.5 mg; 1 mg; 2 mg)
Drug class: Meglitinides
GENERIC STATUS: Lower-cost generic available
AVAILABILITY: Prescription only

Before taking Repaglinide:

If you have type 1 diabetes, diabetic ketoacidosis, significant liver damage, you should not take repaglinide.
Repaglinide should not be taken with gemfibrozil or NPH insulin (such as isophane insulin).
Tell your doctor if you are allergic to repaglinide or if you have any other allergies before taking it.
Do not drive, operate machinery, or engage in any activity that necessitates alertness or clear vision until you are certain you can do so safely.
Alcohol should be avoided when taking this medication since it increases the risk of low blood sugar.
Tell your doctor and pharmacist what prescription and over-the-counter drugs, Ayurvedic medicines, vitamins, nutritional supplements, and herbal products you're taking or planning to use.
There has been no evidence of a link between repaglinide use and significant birth abnormalities, miscarriage, or unfavorable maternal or fetal outcomes in pregnant women. However, it is not advised for use by pregnant women. Make an appointment with your physician.
Breast milk does not contain it. However, you should not breastfeed while using Repaglinide without first seeing your doctor. Repaglinide is not indicated for usage while breastfeeding since it has the potential to produce low blood sugar in breastfed newborns.

How should Repaglinide be used?

Before you start taking repaglinide, and every time you get a refill, read the Patient Information Leaflet if one is available from your pharmacist.
Repaglinide is available as a tablet to be swallowed. The tablets are given 30 minutes to just before a meal, depending on the time of day.
It is recommended that when a person misses the food, he must skip the repaglinide dose. He will have to wait till your next meal.
You'll need to take an extra dose of repaglinide if you eat an extra meal.
Depending on your response to repaglinide, your doctor may gradually increase your dose.
Do not take more or less of it, or take it more frequently than the package label or your doctor recommends.
Repaglinide dose is mainly often given 2 to 4 times a day, 30 minutes before a meal.
Diet, exercise, weight control, blood sugar testing, and specific medical care may all be part of a treatment plan that includes repaglinide.
Pay strict attention to your doctor's recommendations.

Common Side Effects of Repaglinide

low blood sugar
nausea
diarrhea
headache
back pain
joint pain
cold symptoms
constipation,
stomach pain,
upper respiratory infection
chest pain.

Serious Side Effects of Repaglinide

confusion
seizures
loss of consciousness
extreme thirst
frequent urination
extreme hunger
weakness
blurred vision
pale or yellowed skin
dark-colored urine
pancreatitis

Storage and Disposable information regarding Repaglinide

Store the medicine between 20 and 25 degrees Celsius (68 and 77 degrees Fahrenheit).
Moisture should be avoided. Keep bottles as close together as possible.
Dispense in child-resistant containers with child-resistant lids.
Unused prescriptions should be disposed of in a certain manner to prevent pets, children, and others from ingesting them, A medicine take-back program is an ideal approach to get rid of your medication.

Dosage Information of Repaglinide:

Dosage Forms & Strengths consist of 0.5mg; 1mg; 2mg

Usual Adult Dose for Diabetes Type 2:

Take 30 minutes before a meal to get the most out of it (skip the dose if the meal is skipped; add dose if the meal is added).
In reaction to variations in eating patterns, it could be dosed 2, 3, or 4 times a day.
Range of doses: before meals (0.5-4 mg)
Daily maximum dose: Do not take more than 16 mg per day.

Starting dose

0.5 mg PO before each meal if HbA1c is less than 8%
1-2 mg PO before each meal if HbA1c is less than 8%

Dosage adjustment

Increase the dose to 4 mg with each meal until glycemic control is good.
After each dose modification, wait at least 1 week to check response.
To reduce the risk of hypoglycemia, instruct patients to skip their regular repaglinide dose.
Reduce the repaglinide dose if hypoglycemia occurs.

PEDIATRIC: Safety and efficacy have yet to be determined. Consult your physician.

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