Top 156 Pioglitazone Manufacturers In India

Pioglitazone Manufacturers In India  | Pioglitazone Tablets Third Party Pharma Manufacturing Companies

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What is pioglitazone?

• Pioglitazone is an antihyperglycemic drug used to treat type 2 diabetes mellitus in combination with diet, exercise, and other anti-diabetic medications.
• Though there is no pharmacologic difference between the enantiomers and they appear to interconvert in vivo with minimal impact, it is given as a racemic mixture.

Use of Pioglitazone

• In individuals with type 2 diabetes, pioglitazone is used in conjunction with diet and exercise to enhance blood sugar management.
• Pioglitazone is not approved for the treatment of type 1 diabetes.
• Diabetes Mellitus is treated using this medication.
• Other applications include Diabetic Coma is a condition caused by diabetes (in DM Type II)
• This drug may be recommended by your doctor if you have Diabetic Ketoacidosis (in DM Type II)

General Information:

• The Generic name is pioglitazone (PYE o GLIT a zone)
• Dosage forms consist of the oral tablets (15 mg; 30 mg; 45 mg)
• Drug class: Antidiabetics, Thiazolidinediones
• DrugBank Accession Number: DB01132
• Type: Small Molecule
• Groups: Approved, Investigational
• Synonyms: Pioglitazone; Pioglitazona; Pioglitazonum
• Associated Conditions: Diabetes; Type 2 Diabetes Mellitus; Diabetic Neuropathies

Some Important Precautions while taking Pioglitazone

• If you are allergic to pioglitazone, any other medications, or any of the ingredients in pioglitazone tablets, tell your doctor right away. For a list of ingredients of medicine, ask your pharmacist.
• Tell your doctor about all of the prescription and nonprescription medications, over-the-counter medicines, vitamins, nutritional supplements, and herbal products you're using or planning to use.
• If you have or have ever had bladder cancer,  diabetic eye disease, kidney or liver disease, congestive heart failure or heart disease, or any of the diseases and conditions listed in the IMPORTANT WARNING section, or if you have or have ever had any of the diseases and conditions listed in the IMPORTANT WARNING section, consult your health care specialist.
• Follow her doctor's guidance about using this medication if the woman is pregnant or you become pregnant.
• There is no information on pioglitazone's presence in human milk, its effects on breastfed infants, or its impact on milk production. Breastfeeding's developmental and health benefits should be examined alongside the mother's clinical requirement for pioglitazone and any potential detrimental effects of pioglitazone or the underlying maternal disease on the breastfed newborn.
• Even if you do not have regular monthly periods or if you have a condition that prevents you from ovulating, pioglitazone may enhance your chances of becoming pregnant if you have not yet reached menopause (change of life; end of monthly periods) (releasing an egg from the ovaries). Consult your doctor about birth control options that are right for you.
• Stress, surgery, exercise, illness, alcohol consumption, and meal skipping can all impact blood sugar levels.
  Before changing your prescription dose or schedule, consult your doctor.

How should I take pioglitazone?

• Read your medication label carefully and follow all of the advice on it.
• Pioglitazone is taken with or without food, according to your doctor's recommendations for dose and duration.
• Along with Pioglitazone, you should continue to exercise regularly, consume a nutritious diet, and take your other diabetic medications.
• You may feel unusually hungry, dizzy, irritated, confused, anxious, or shaky if you have low blood sugar (hypoglycemia). Eat or drink a fast-acting source of sugar to quickly correct hypoglycemia (hard candy, fruit juice, raisins, crackers, or non-diet soda).
• If you have severe hypoglycemia, your physician may appoint a glucagon injection kit. In case of an emergency, make sure your family or close friends know how to administer this injection.
• After a few weeks on Pioglitazone, the full effects may become apparent. Continue to take your medicine as directed by your health care specialist.
• Your liver function may be monitored regularly by your health care specialist. If you have symptoms such as abdominal pain, yellowing of the eyes, or a loss of appetite, contact your doctor.

Dosage Information of pioglitazone

Pioglitazone comes in the form of Tablet: 15 mg, 30 mg, 45 mg

Adults: Take 15 or 30 milligrams (mg) once a day initially. If necessary, your health care specialist may change your medicine dose. However, the daily intake is usually limited to 45 mg.

For Type 2 Diabetes Mellitus Patients

• It can be used alone or in combination with insulin or insulin secretagogues.
• Initially, take 15-30 mg orally with a meal once a day; gradually raise the dose by 15 mg per day, with careful monitoring, to 45 mg per day.
• ALT levels should be checked at the beginning of treatment, once a month for the first 12 months, and then every three months following that.

Dosage Modification

• Coadministration with a sulfonylurea (insulin secretagogue): Reduce the amount of insulin secretagogue you're taking.
• Insulin co-administration: Reduce insulin dosage by 10% to 25%.
• Strong CYP2C8 inhibitors (gemfibrozil) should not be taken together. The maximum daily dose of pioglitazone should not exceed 15 mg.

Use and dosage in children must be established by your doctor.

Common Side Effects of pioglitazone:

• Chest pain
• decreased urine output
• dilated neck veins
• extreme fatigue
• irregular breathing
• irregular heartbeat
• problems with teeth
• swelling of the fingers, feet, face, or lower legs
• tightness in the chest
• trouble breathing
• weight gain

Serious Side Effects of Pioglitazone:

• Anemia
• Liver injury
• Edema
• Fractures
• Bladder cancer
• Diabetic macular edema
• Breath Shortness
• unusual exhaustion
• swelling
• rapid weight gain
• pink or crimson urine, painful or difficult urination, new or increasing urge to urinate
• vision changes
• sudden unusual pain in your arm, hand, or foot

What happens if I miss a dose or Overdose pioglitazone?

• Take the medicine as soon as possible, but if your next dose is approaching, skip the missed dose. Do not take two doses of the medicine at once.
• Extreme weakness, sweating, impaired vision, difficulty speaking, stomach ache, tremors, confusion, and seizure are all symptoms of low blood sugar (convulsions).

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