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We have discussed some of the most important information about Glibenclamide in this blog. Read the blog and get yourself ready for investing in the Glibenclamide market.

What is Glibenclamide and how it works?

Glibenclamide is an antidiabetic medication that belongs to the oral hypoglycaemics class of drugs. It lowers blood glucose levels by increasing the amount of insulin secreted by the pancreas.
Glibenclamide is a sulfonylurea of the second generation. It's usually given to people who aren't responding to metformin, the traditional first-line treatment. Glibenclamide increases intracellular potassium and calcium ion concentrations and enhances insulin production by closing ATP-sensitive potassium channels on beta cells.
Glibenclamide was approved by the FDA on May 1, 1984.
On July 31, 2000, the FDA approved a metformin formulation.

Uses of Glibenclamide:

Glibenclamide is a drug that is used to treat type 2 diabetes. The medicine is taken in combination with proper diet and exercise to help persons with type 2 diabetes control their blood sugar levels.

General information:

The generic Name is Glyburide
DrugBank Accession Number: DB01016
Type of Medicines: A sulfonylurea anti-diabetic medication
Available in the form of Tablet, Oral Liquid Medicine
Type: Small Molecule
Groups: Approved
Synonyms mainly are Glibenclamida, Glibenclamidum, Glibenclamide, Glyburide
Associated Conditions: Glycemic Control, Type 2 Diabetes Mellitus, Gestational Diabetes Mellitus (GDM)

Precaution is taken before taking Glibenclamide?

If you are allergic to this drug or any of its other ingredients, tell your doctor right away.
If you have Glucose-6 Phosphate Dehydrogenase (G6PD) deficiency, severe thyroid or adrenal gland problems, or have ever been in a diabetic coma, tell your doctor.
Talk to her doctor if the woman is pregnant or planning to get pregnant. It is not recommended that pregnant women take this medicine unless it is absolutely necessary. It should only be used when the advantages clearly outweigh the risks.
This medicine should not be taken if the mother is breastfeeding. If this medicine is used, the infant may need to be monitored for signs of low blood sugar. Before consuming this medication, consult your doctor.
If you have a heart problem, a kidney problem, or a liver problem, you should talk to your doctor about it.
If you are an alcoholic, consult your doctor. When you're using this prescription to control your blood sugar levels, it's not a good idea to drink a lot of alcohol.
Due to illness or a change in diet, you are eating less than usual, and your medication dosage may need to be adjusted.
You should not drive or operate machinery if you have signs of low blood sugar (hypoglycemia). Low blood sugar may occur at the start of treatment as your doctor determines the appropriate dose for you. Your doctor will provide you with additional guidance. You can drive or operate machines once your blood sugar has normalized.

How to take glibenclamide

Read the manufacturer's written guidelines sheet from within the carton before starting the treatment.
Before a meal, take the tablet(s) as advised by your doctor (s). An adult's normal beginning dose is 5 mg per day. It's given as a single dose, to be taken with or shortly after breakfast.
After taking the drug, do not skip or delay meals.
A child's dose will vary based on their body weight, and they may need to take it more than once each day; carefully follow your doctor's directions.
If you (or your child) have been given oral liquid medicine, be sure to use the oral syringe and adaptor provided to measure the exact amount. Follow the written directions in the manufacturer's circular.
If you're administering the oral liquid medicine to a baby, give it about 15 minutes before he or she gets a milk feed.

Common Side Effects of Glibenclamide

Nausea
Heartburn
Fast heartbeat
Unusual tiredness and weakness
Vomiting
loose stools
dizziness
hunger
sweating

Serious Side Effects

Yellowing of skin and eyes
Dark-colored urine
Fever or chills
Swelling of lips, face, eyelids, hands, tongue, and feet
Unusual bleeding
Allergic reactions (including inflammation of blood vessels, which typically results in a skin rash) might proceed to serious symptoms, including trouble breathing, a drop in blood pressure, and even shock.
Abnormal liver function, including skin and eye yellowing (jaundice) Cholestasis, hepatitis, or liver failure are all conditions that affect the flow of bile.
Itching, rash, hives, and heightened sensitivity to the sun are all symptoms of skin allergy (hypersensitivity). Some moderate allergic responses can progress to more serious ones, resulting in severe blistering of the skin, lips, eyes, and genitals. Loss of consciousness, convulsions, or coma is all symptoms of severe hypoglycemia.

How to store glibenclamide

All medications should be kept out of reach and sight of dogs and children.
Keep the medicine away from direct heat and light and always store it in a cool, dry location.
After opening, the oral liquid drug should not be used for longer than 30 days. It's a good idea to write the date you first opened the bottle on the label.

Missed or Overdose of glibenclamide

If you miss a dose, omit the missed dose and take your next dose right before your next meal. To make up for a missing dose, do not increase your dose or take extra medicine.

If the patient suspects an overdose, call his/her doctor right once. Confusion, sweating, weakness, vomiting, fainting, seizures, and other symptoms of an overdose may occur.