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Canagliflozin Manufacturers In India

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Canagliflozin 100/ 300 mg 

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Canagliflozin Manufacturers In India | Canagliflozin Third Party Pharma Manufacturing Companies

Canagliflozin Manufacturers In India - Canagliflozin is an oral diabetic medication that aids in blood sugar control. During the projected period 2021-2027, the global Canagliflozin market is expected to grow at a significant rate. The market is expected to develop at a steady rate through 2021, thanks to the increasing adoption of tactics by the Best Canagliflozin Manufacturers In India. If you are thinking of investing in the Canagliflozin market then we can help you in providing the best list of Canagliflozin Manufacturing companies In India.

Further, Read the given article about some of the important information about Canagliflozin and come back to us for further inquiries.

What is canagliflozin?

  • The sodium-glucose cotransporter 2 (SGLT2) inhibitor canagliflozin, also known as Invokana, is used to treat diabetes.
  • The FDA first approved it in 2013 for diabetes management, and then again in 2018 for a second indication of lowering the risk of cardiovascular events in people with type 2 diabetes mellitus.
  • Canagliflozin was the first oral diabetes medication to be approved for the prevention of cardiovascular events in people with type 2 diabetes.
  • As blood flows through the kidneys, glucose is filtered out of the blood and into the tubules of the kidneys. The glucose is then taken back into the bloodstream by the tubules, preventing glucose loss in the urine.
  • SGLT2 is an enzyme found in the tubules of the kidney that allows glucose to be reabsorbed from the urine. SGLT2 is inhibited by canagliflozin.
  • As a result, canagliflozin inhibits glucose reabsorption from renal tubules, resulting in increased glucose excretion in urine.

Uses of Canagliflozin?

  • In individuals with type 2 diabetes, canagliflozin is used in conjunction with diet and exercise to regulate blood sugar (glucose).
  • In individuals with type 2 diabetes who have a history of cardiovascular illness, the medication is used to reduce the risk of serious cardiovascular events such as heart attack, stroke, heart failure, or death.
  • In adults with type 2 diabetes and diabetic kidney disease (nephropathy) who have a certain quantity of protein in their urine, canagliflozin is also used to minimize the risk of end-stage kidney disease (ESKD), worsening renal function, cardiovascular mortality, and hospitalization for heart failure.
  • Type 1 diabetes is not treated with canagliflozin.
  • Canagliflozin may also be used for other reasons not included in this patient information sheet.

General Information:

  • DrugBank Accession Number: DB08907
  • Generic name is canagliflozin (KAN a gli FLOE zin)
  • Dosage forms consist of the oral tablets (100 mg; 300 mg)
  • Drug class: SGLT-2 inhibitors
  • Type: Small Molecule
  • Groups: Approved
  • Synonyms: Canagliflozin; Canagliflozina
  • Associated Conditions: Hospitalizations; Major Adverse Cardiac Events; Cardiovascular Mortality; End-Stage Renal Disease (ESRD); Type 2 Diabetes Mellitus; Doubling of serum creatinine

Before taking Canagliflozin

  • If you are allergic to canagliflozin, any other drugs, or any of the ingredients in canagliflozin tablets, tell your doctor and pharmacist.
  • Tell your doctor and pharmacist about any additional prescription and nonprescription medications, over-the-counter medications, vitamins, nutritional supplements, and herbal products you're using or planning to use.
  • If you're on dialysis, let your doctor know. It's possible that your doctor will advise you not to use canagliflozin.
  • If you often consume alcohol or consume substantial amounts of alcohol in a short period of time, or if you are on a low sodium diet, tell your doctor.
  • Consult your doctor if you are pregnant or planning pregnancy.
  • If you are breastfeeding do take advice from a doctor while using this medicine.
  • Tell your doctor or dentist that you are taking canagliflozin if you are having surgery, including dental surgery.
  • Alcohol can cause blood sugar levels to fluctuate. Consult your doctor about the safe consumption of alcoholic beverages while on canagliflozin.
  • In the event that you become ill, acquire an infection or fever, experience extraordinary stress, or are harmed, consult your doctor. These disorders may have an impact on your blood sugar levels and the amount of canagliflozin you require.
  • Tell your doctor if you have ever had a diabetic foot ulcer or amputation; heart problems; circulation problems or nerve problems in your legs or feet; bladder infections; kidney disease; liver disease; or other urination problems; a pancreas disorder.

How should Canagliflozin be used?

  • Before you start taking canagliflozin, read the Medication Guide issued by your pharmacist.
  • The dosage is determined by your medical condition, treatment response, and any other medications you are taking.
  • Take Canagliflozin precisely as your doctor prescribes. The pill should be taken whole with the water. Your tablet can be taken with or without food.
  • It's ideal to take it first thing in the morning, preferably at the same time every day. This will make it simpler for you to remember to take the medicine.
  • To regulate blood sugar and avoid long-term problems, canagliflozin is used alone or in combination with other diabetic medications.
  • To receive the best benefit from this drug, take it on a daily basis. Take it at the same time every day to help you remember.
  • If your condition does not improve or worsen (for example, if your blood sugar remains high or rises), contact your doctor.
  • If you are going through any disease then you should consult your doctor as the medical tests may be affected by this medicine. Any doctor who treats you should be aware that you are taking canagliflozin.

Common Side Effects of Canagliflozin

  • Frequent urination
  • unusual dry mouth
  • dizziness,
  • lightheadedness
  • female genital fungal infections
  • Urinary tract infection
  • Increased thirst
  • Nausea

Serious Side Effects of Canagliflozin

  • Lower Limb Amputation
  • Volume Depletion
  • Ketoacidosis
  • Urosepsis and Pyelonephritis
  • Hypoglycemia Necrotizing Fasciitis of the Perineum (Fournier’s gangrene)
  • Genital Mycotic Infections
  • Hypersensitivity Reactions
  • decrease in the amount of urine
  • urine that is red, cloudy, pink, or brown
  • strong-smelling urine
  • pelvic or rectal pain
  • Vaginal odor or vaginal itching (in women) Vaginal discharge that is white or yellowish in color (may be lumpy or appear like cottage cheese) 
  • (in men) Penis itchiness, redness, or swelling; discharge from the penis that has a bad odor; a rash on the penis; or soreness in the skin around the penis;
  • redness, fever, pain, tenderness, and swelling of the genitals or the area between the genitals and the rectum.
In case of emergency/overdose or the missed dose of Canagliflozin

In the case of an overdose of the drug, contact a poison control center. If the sufferer has passed out, is having problems breathing, has had a seizure, or cannot be woken, contact the emergency helpline right once.

Take the medicine that you are taking as soon as possible, but if your following dose is progressing, avoid the missed dose. Do not combine two dosages of your medication at once.

Storage Information about Canagliflozin

Canagliflozin Tablets should be kept at room temperature, between 15 and 30 degrees Celsius (59 F to 86 F)

Canagliflozin Dosage Forms & Strengths
  • The medication is available in 100mg and 300mg tablet form.
  • In patients with Type 2 Diabetes Mellitus, the first dose is 100 mg PO a day taken before the first meal of the day. If 100 mg/day is tolerated in patients with eGFR 60 mL/min/1.73 m2 who require extra glycemic control, the dose may be increased to 300 mg daily.
  • When compared to younger patients, patients over 65 years old had a higher incidence of adverse reactions related to reduced intravascular volume (eg, hypotension, postural dizziness, orthostatic hypotension, syncope, dehydration), especially with the 300 mg daily dose; a more prominent increase in the incidence was seen in patients over 75 years old.

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